Key features and details
- Suitable for: Functional Studies, HPLC
Product nameSGK peptide
See all SGK proteins and peptides
Our Abpromise guarantee covers the use of ab204871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab204871 (SGK peptide) can be utilized as a substrate for the active protein kinase ab125530 (Active human STK38L full length protein)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
- Serine threonine protein kinase Sgk1
- Serum glucocorticoid regulated kinase
RelevanceSGK is a protein kinase that plays an important role in cellular stress response. It activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is rapidly induced in response to a variety of stimuli, including serum, hormones, and osmotic shock. At sustained high levels and activity it may contribute to conditions such as hypertension and diabetic nephropathy. SGK can also mediate cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.
Cellular localizationCytoplasmic and nuclear, upon phosphorylation.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab204871 has not yet been referenced specifically in any publications.