Overview

Description

  • Nature

    Synthetic
  • Amino Acid Sequence
    • Sequence

      CKKRNRRLSVA

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

  • Form

    Liquid
  • Additional notes

    ab204871 (SGK peptide) can be utilized as a substrate for the active protein kinase ab125530 (Active human STK38L full length protein)

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • Serine threonine protein kinase Sgk1
    • Serum glucocorticoid regulated kinase
    • SGK1
  • Relevance

    SGK is a protein kinase that plays an important role in cellular stress response. It activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is rapidly induced in response to a variety of stimuli, including serum, hormones, and osmotic shock. At sustained high levels and activity it may contribute to conditions such as hypertension and diabetic nephropathy. SGK can also mediate cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.
  • Cellular localization

    Cytoplasmic and nuclear, upon phosphorylation.

References

ab204871 has not yet been referenced specifically in any publications.

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