Key features and details
- Mouse polyclonal to SGSH/HSS
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SGSH/HSS antibody
See all SGSH/HSS primary antibodies
DescriptionMouse polyclonal to SGSH/HSS
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Full length protein corresponding to Human SGSH/HSS.
Database link: NP_000190.1
- SGSH/HSS transfected 293T cell line
This product was previously labelled as SGSH
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.40
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab72617 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 57 kDa.|
Involvement in diseaseDefects in SGSH are the cause of mucopolysaccharidosis type 3A (MPS3A) [MIM:252900]; also known as Sanfilippo syndrome A. MPS3A is a severe form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life. MPS3A is characterized by earlier onset, rapid progression of symptoms and shorter survival.
Sequence similaritiesBelongs to the sulfatase family.
modificationsThe conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
- Information by UniProt
- Heparan sulfate sulfatase antibody
- Heparan sulphate sulphatase antibody
- HSS antibody
All lanes : Anti-SGSH/HSS antibody (ab72617) at 1/500 dilution
Lane 1 : SGSH/HSS transfected 293T cell line
Lane 2 : Non transfected 293T cell line
Lysates/proteins at 25 µg per lane.
Lane 1 : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Lane 2 : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Developed using the ECL technique.
Predicted band size: 57 kDa
Observed band size: 67 kDa why is the actual band size different from the predicted?
ab72617 has not yet been referenced specifically in any publications.