Overview

  • Product name

    SH-6, Akt inhibitor
  • Description

    Phosphatidylinositol analog; selective Akt inhibitor
  • Biological description

    Phosphatidylinositol analog. Selective Akt inhibitor, prevents Akt translocation to the membrane. Has no effect on other downstream kinases. Induces apoptosis.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Firat E  et al. Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote ?-irradiation-induced cell death in primary stem-like glioma cells. PLoS One 7:e47357 (2012). Read more (PubMed: 23091617) »
  • Krech T  et al. Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations. BMC Cancer 10:287 (2010). Read more (PubMed: 20546605) »
  • Van Meter TE  et al. Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas. Cancer 107:2446-54 (2006). Read more (PubMed: 17041888) »

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