Overview

  • Product name

  • Description

    Rabbit polyclonal to SH2D1A/SAP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human SH2D1A/SAP.
    Database link: O60880

  • Positive control

    • Thymus cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab185810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 14 kDa.
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
  • Tissue specificity

    Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
  • Involvement in disease

    Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • Sequence similarities

    Contains 1 SH2 domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • DSHP antibody
    • Duncan disease SH2 protein antibody
    • Duncan disease SH2-protein antibody
    • EBVS antibody
    • IMD5 antibody
    • LYP antibody
    • MTCP1 antibody
    • SAP antibody
    • SAP/SH2D1A antibody
    • SH2 domain containing 1A antibody
    • SH2 domain protein 1A antibody
    • SH2 domain-containing protein 1A antibody
    • SH21A_HUMAN antibody
    • SH2D1A antibody
    • Signaling lymphocyte activation molecule associated protein antibody
    • Signaling lymphocytic activation molecule-associated protein antibody
    • SLAM associated protein antibody
    • SLAM associated protein/SH2 domain protein 1A antibody
    • SLAM-associated protein antibody
    • T cell signal transduction molecule SAP antibody
    • T-cell signal transduction molecule SAP antibody
    • XLP antibody
    • XLPD antibody
    see all

Images

  • Anti-SH2D1A/SAP antibody (ab185810) at 1/500 dilution + Thymus cell lysate

    Predicted band size: 14 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling SH2D1A/SAP with ab185810 at 1/200. Magnification: 400x.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling SH2D1A/SAP with ab185810 at 1/200. Magnification: 400x.
  • Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab185810. Blue DAPI for nuclear staining.

References

ab185810 has not yet been referenced specifically in any publications.

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