Overview

  • Product name
  • Description
    Goat polyclonal to SH2D1A/SAP
  • Host species
    Goat
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    HKRYFRKIKN

    , corresponding to Internal sequence amino acids 73/82 of Human SH2D1A/SAP

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab36141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1:16,000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 14 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
    • Tissue specificity
      Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
    • Involvement in disease
      Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
    • Sequence similarities
      Contains 1 SH2 domain.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • DSHP antibody
      • Duncan disease SH2 protein antibody
      • Duncan disease SH2-protein antibody
      • EBVS antibody
      • IMD5 antibody
      • LYP antibody
      • MTCP1 antibody
      • SAP antibody
      • SAP/SH2D1A antibody
      • SH2 domain containing 1A antibody
      • SH2 domain protein 1A antibody
      • SH2 domain-containing protein 1A antibody
      • SH21A_HUMAN antibody
      • SH2D1A antibody
      • Signaling lymphocyte activation molecule associated protein antibody
      • Signaling lymphocytic activation molecule-associated protein antibody
      • SLAM associated protein antibody
      • SLAM associated protein/SH2 domain protein 1A antibody
      • SLAM-associated protein antibody
      • T cell signal transduction molecule SAP antibody
      • T-cell signal transduction molecule SAP antibody
      • XLP antibody
      • XLPD antibody
      see all

    Images

    References

    ab36141 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Question
    Answer

    DISCOUNT CODE: *******
    Expiration date: *********

    I am very pleased to hear you would like to accept our offer and test ab36141 in IF/ICC. This code will give you: 1 free PRIMARY ANTIBODY before the expiration date. To redeem this offer, please submit an Abreview forIF/ICC and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.


    Remember, we publish both positive and negative Abreviews on our datasheets so please submit the results of your tests. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.

    Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.

    The terms and conditions applicable to this offer can be found here: www.abcam.com/collaborationdiscount.

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