Anti-SH3BP2 antibody (ab117833)
Key features and details
- Rabbit polyclonal to SH3BP2
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-SH3BP2 antibody
See all SH3BP2 primary antibodies -
Description
Rabbit polyclonal to SH3BP2 -
Host species
Rabbit -
Tested applications
Suitable for: IPmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rhesus monkey, Gorilla, Orangutan -
Immunogen
Synthetic peptide, corresponding to a region within amino acids 400-450 of Human SH3BP2 (NP_001116153.1).
-
Positive control
- HeLa whole cell lysate.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH: 7-8 -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Purification notes
ab117833 was affinity purified using an epitope specific to SH3BP2 immobilized on solid support. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117833 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IP |
Use at 2-10 µg/mg of lysate.
|
Notes |
---|
IP
Use at 2-10 µg/mg of lysate. |
Target
-
Function
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. -
Tissue specificity
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. -
Involvement in disease
Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling. -
Sequence similarities
Contains 1 PH domain.
Contains 1 SH2 domain. - Information by UniProt
-
Database links
- Entrez Gene: 6452 Human
- Omim: 602104 Human
- SwissProt: P78314 Human
- Unigene: 167679 Human
-
Alternative names
- 3BP-2 antibody
- 3BP2 antibody
- 3BP2_HUMAN antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab117833 has not yet been referenced specifically in any publications.