Key features and details
- Rabbit polyclonal to SH3BP2
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SH3BP2 antibody
See all SH3BP2 primary antibodies
DescriptionRabbit polyclonal to SH3BP2
Tested applicationsSuitable for: IPmore details
Unsuitable for: WB
Species reactivityReacts with: Human
Predicted to work with: Rhesus monkey, Gorilla, Orangutan
Synthetic peptide, corresponding to a region within amino acids 400-450 of Human SH3BP2 (NP_001116153.1).
- HeLa whole cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab117833 was affinity purified using an epitope specific to SH3BP2 immobilized on solid support.
Our Abpromise guarantee covers the use of ab117833 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at 2-10 µg/mg of lysate.|
FunctionBinds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Tissue specificityExpressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
Involvement in diseaseDefects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
Sequence similaritiesContains 1 PH domain.
Contains 1 SH2 domain.
- Information by UniProt
- 3BP-2 antibody
- 3BP2 antibody
- 3BP2_HUMAN antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab117833 has not yet been referenced specifically in any publications.