Overview

  • Product name

  • Description

    Rabbit polyclonal to SH3PX1/SNX9
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human SH3PX1/SNX9 aa 500-550 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    LGCFPDIIGTH KGAIEKVKES DKLVATSKIT LQDKQNMVKR VSIMSYALQA


    Database link: Q9Y5X1

  • Positive control

    • Rat kidney tissue.
  • General notes

     This product was previously labelled as SH3PX1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab216836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
  • Sequence similarities

    Belongs to the sorting nexin family.
    Contains 1 BAR domain.
    Contains 1 PX (phox homology) domain.
    Contains 1 SH3 domain.
  • Domain

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol-4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
  • Post-translational
    modifications

    Ubiquitinated by ITCH.
    Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
  • Cellular localization

    Cytoplasmic vesicle membrane. Cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle. Golgi apparatus > trans-Golgi network. Cell projection > ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • MST 155 antibody
    • MST155 antibody
    • MSTP 155 antibody
    • MSTP155 antibody
    • OTTHUMP00000040083 antibody
    • Protein SDP 1 antibody
    • Protein SDP1 antibody
    • SDP 1 antibody
    • SDP1 antibody
    • SH3 and PX domain containing protein 3A antibody
    • SH3 and PX domain containing protein SH3PX1 antibody
    • SH3 and PX domain-containing protein 1 antibody
    • SH3 and PX domain-containing protein 3A antibody
    • SH3PX1 antibody
    • SH3PXD3A antibody
    • SNX 9 antibody
    • SNX9 antibody
    • SNX9_HUMAN antibody
    • Sorting nexin 9 antibody
    • Sorting nexin-9 antibody
    • WASP interactor protein antibody
    • Wiskott Aldrich syndrome protein (WASP) interactor protein antibody
    • Wiskott Aldrich syndrome protein interactor protein antibody
    • WISP antibody
    see all

Images

  • Immunohistochemical analysis of PFA-fixed, paraffin-embedded Rat kidney tissue labeling SH3PX1/SNX9 with ab216836 at 1/500 dilution overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining.

References

ab216836 has not yet been referenced specifically in any publications.

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