Product nameAnti-SHANK1 antibody [M369]
See all SHANK1 primary antibodies
DescriptionMouse monoclonal [M369] to SHANK1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Predicted to work with: Rat, Human
A sequence corresponding to amino acids in the C terminal region of Rat SHANK1.
- Mouse brain lysate.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.1% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab157766 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 225 kDa (predicted molecular weight: 226 kDa).|
FunctionSeems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Tissue specificityExpressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
Sequence similaritiesBelongs to the SHANK family.
Contains 6 ANK repeats.
Contains 1 PDZ (DHR) domain.
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 SH3 domain.
Cellular localizationCytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Postsynaptic density of neuronal cells.
- Information by UniProt
- GKAP/SAPAP interacting protein antibody
- OTTHUMP00000174437 antibody
- SH3 and multiple ankyrin repeat domains 1 antibody
Lane 1 : Anti-SHANK1 antibody [M369] (ab157766) at 1/250 dilution
Lane 2 : Anti-SHANK1 antibody [M369] (ab157766) at 1/500 dilution
Lane 3 : Anti-SHANK1 antibody [M369] (ab157766) at 1/1000 dilution
All lanes : Mouse brain lysate.
Predicted band size: 226 kDa
Observed band size: 225 kDa why is the actual band size different from the predicted?
ab157766 has not yet been referenced specifically in any publications.