Overview

  • Product name

    Anti-SHANK1 antibody [M369]
    See all SHANK1 primary antibodies
  • Description

    Mouse monoclonal [M369] to SHANK1
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    A sequence corresponding to amino acids in the C terminal region of Rat SHANK1.

  • Positive control

    • Mouse brain lysate.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.1% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    M369
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab157766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 225 kDa (predicted molecular weight: 226 kDa).

Target

  • Function

    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • Tissue specificity

    Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
  • Sequence similarities

    Belongs to the SHANK family.
    Contains 6 ANK repeats.
    Contains 1 PDZ (DHR) domain.
    Contains 1 SAM (sterile alpha motif) domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Postsynaptic density of neuronal cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • GKAP/SAPAP interacting protein antibody
    • OTTHUMP00000174437 antibody
    • SH3 and multiple ankyrin repeat domains 1 antibody
    • SH3 and multiple ankyrin repeat domains protein 1 antibody
    • SH3/ankyrin domain gene 1 antibody
    • SHAN1_HUMAN antibody
    • SHANK 1 antibody
    • Shank1 antibody
    • Shank1a antibody
    • Somatostatin receptor interacting protein antibody
    • Somatostatin receptor-interacting protein antibody
    • SPANK 1 antibody
    • SPANK1 antibody
    • SSTR interacting protein antibody
    • SSTR-interacting protein antibody
    • SSTRIP antibody
    • Synamon antibody
    see all

Images

  • Lane 1 : Anti-SHANK1 antibody [M369] (ab157766) at 1/250 dilution
    Lane 2 : Anti-SHANK1 antibody [M369] (ab157766) at 1/500 dilution
    Lane 3 : Anti-SHANK1 antibody [M369] (ab157766) at 1/1000 dilution

    All lanes : Mouse brain lysate.

    Predicted band size: 226 kDa
    Observed band size: 225 kDa
    why is the actual band size different from the predicted?

References

ab157766 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab157766.
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