Key features and details
- Rabbit polyclonal to Shoc2 / Sur8
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Shoc2 / Sur8 antibody
See all Shoc2 / Sur8 primary antibodies
DescriptionRabbit polyclonal to Shoc2 / Sur8
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
A 21 amino acid peptide near the N terminus of Human Shoc2/ Sur8 (NP_031399).
- Jurkat cell lysate; Human spleen tissue
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab106430 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa.|
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionRegulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Involvement in diseaseDefects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) [MIM:607721]. NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
Sequence similaritiesBelongs to the SHOC2 family.
Contains 20 LRR (leucine-rich) repeats.
Cellular localizationCytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation.
- Information by UniProt
- KIAA0862 antibody
- Leucine-rich repeat protein SHOC-2 antibody
- Protein soc-2 homolog antibody
Lane 1 : Anti-Shoc2 / Sur8 antibody (ab106430) at 1 µg/ml
Lane 2 : Anti-Shoc2 / Sur8 antibody (ab106430) at 2 µg/ml
All lanes : Jurkat cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 65 kDa
ab106430, at 5 µg/ml, staining Shoc2 / Sur8 in paraffin embedded Human spleen tissue by Immunohistochemistry.
ab106430 has been referenced in 2 publications.
- Xie CM et al. The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. Cell Rep 26:3037-3050.e4 (2019). PubMed: 30865892
- Yen I et al. Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors. Cancer Cell 34:611-625.e7 (2018). PubMed: 30300582