Key features and details
- Mouse monoclonal [M160] to SHP1
- Suitable for: WB, IP, ELISA, ICC
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-SHP1 antibody [M160]
See all SHP1 primary antibodies
DescriptionMouse monoclonal [M160] to SHP1
Specificityab76202 does not cross-react with SHP2.
Tested applicationsSuitable for: WB, IP, ELISA, ICCmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant protein containing amino acids in the C terminal region of human SHP1.
- Jurkat cells treated with pervanadate (1 mM) for 30 min.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab76202 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).|
FunctionPlays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
Tissue specificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.
modificationsPhosphorylated on serine and tyrosine residues.
Cellular localizationCytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
- Information by UniProt
- 70Z-SHP antibody
- EC 220.127.116.11 antibody
- HCP antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab76202 has been referenced in 1 publication.
- Wang S et al. YB1 protects cardiac myocytes against H2O2-induced injury via suppression of PIAS3 mRNA and phosphorylation of STAT3. Mol Med Rep 19:4579-4588 (2019). PubMed: 30942400