SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (ab141164)

Overview

  • Product name

    SHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist
  • Description

    Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist
  • Biological description

    Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (IC50 values are 0.23 and 0.06 nM, respectively). Also shows MC5 partial agonist activity (EC50 = 0.12 nM). Dose-dependently increases food intake following central administration.
  • Purity

    > 95%
  • CAS Number

    168482-23-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Roseberry AG Altered feeding and body weight following melanocortin administration to the ventral tegmental area in adult rats. Psychopharmacology (Berl) : (2012). Read more (PubMed: 23010797) »
  • Grieco P  et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides 28:1191-6 (2007). Read more (PubMed: 17482720) »
  • Schuhler S  et al. Feeding and behavioural effects of central administration of the melanocortin 3/4-R antagonist SHU9119 in obese and lean Siberian hamsters. Behav Brain Res 152:177-85 (2004). Read more (PubMed: 15196785) »

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