Key features and details
- Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist
- CAS Number: 168482-23-3
- Purity: > 95%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Product nameSHU9119, Melanocortin 3 and 4 (MC3 and MC4) receptor antagonist
DescriptionPotent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist
Potent melanocortin 3 and 4 (MC3 and MC4) receptor antagonist (IC50 values are 0.23 and 0.06 nM, respectively). Also shows MC5 partial agonist activity (EC50 = 0.12 nM). Dose-dependently increases food intake following central administration.
SequenceXDHXRWK (Modifications: N-terminal acetyl; C-terminal amide; X-1 = D-2-Nal; X-4 = Nle; Cyclised: 2-7)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141164 has been referenced in 2 publications.