• Product name

  • Description

    Rabbit polyclonal to SI
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 1691-1740 (LPCQEPAQNT FYSRQKHMKL IVAADDNQMA QGSLFWDDGE SIDTYERDLY) of Human SI (NP_001032).

  • Positive control

    • Human fetal small intestine lysate



Our Abpromise guarantee covers the use of ab98872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 209 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function

    Plays an important role in the final stage of carbohydrate digestion.
  • Tissue specificity

    Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
  • Involvement in disease

    Defects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
  • Sequence similarities

    Belongs to the glycosyl hydrolase 31 family.
    Contains 2 P-type (trefoil) domains.
  • Post-translational

    The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
  • Cellular localization

    Apical cell membrane. Brush border.
  • Information by UniProt
  • Database links

  • Form

    Sucrase-isomaltase is composed of 2 polypeptide chains of similar size linked together by noncovalent bonds. The polypeptide chains show a high degree of overlapping substrate specificity and are synthesized as 1 long polypeptide chain which, by means of pancreatic proteases, is later split into the 2 subunits.
  • Alternative names

    • Isomaltase antibody
    • MGC131621 antibody
    • MGC131622 antibody
    • Oligosaccharide alpha 1, 6 glucosidase antibody
    • SI antibody
    • sucrase isomaltase alpha glucosidase antibody
    • sucrase isomaltase antibody
    • Sucrase-isomaltase, intestinal antibody
    • SUIS_HUMAN antibody
    see all


  • Anti-SI antibody (ab98872) at 1 µg/ml + Human fetal small intestine lysate at 10 µg

    Predicted band size: 209 kDa


ab98872 has not yet been referenced specifically in any publications.

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