Key features and details
- Rabbit polyclonal to SIGIRR
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SIGIRR antibody
See all SIGIRR primary antibodies
DescriptionRabbit polyclonal to SIGIRR
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Recombinant fragment corresponding to a region within amino acids 54 and 410 of Human SIGIRR (UniProt ID: Q6IA17).
- A549, H1299, HCT116 or MCF7 whole cell lysate; Human gastric cancer tissue.
Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78% PBS, 1% BSA, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab154747 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 46 kDa.|
|IHC-P||1/100 - 1/1000.|
FunctionActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificityMainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similaritiesBelongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.
- Information by UniProt
- Ig IL1 related receptor antibody
- MGC110992 antibody
- SIGIR_HUMAN antibody
All lanes : Anti-SIGIRR antibody (ab154747) at 1/3000 dilution
Lane 1 : A549 whole cell lysate
Lane 2 : H1299 whole cell lysate
Lane 3 : HCT116 whole cell lysate
Lane 4 : MCF7 whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 46 kDa
10% SDS PAGE
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue, labeling SIGIRR using ab154747 at 1/500 dilution.
ab154747 has not yet been referenced specifically in any publications.