Overview

  • Product name

    Anti-SIGIRR antibody [EPR12638]
    See all SIGIRR primary antibodies
  • Description

    Rabbit monoclonal [EPR12638] to SIGIRR
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human SIGIRR aa 1-100 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q6IA17

  • Positive control

    • Fetal kidney lysate.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR12638
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab177937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 46 kDa.
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function

      Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
    • Tissue specificity

      Mainly expressed in epithelial tissues such as kidney, lung and gut.
    • Sequence similarities

      Belongs to the interleukin-1 receptor family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 TIR domain.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Ig IL1 related receptor antibody
      • MGC110992 antibody
      • SIGIR_HUMAN antibody
      • SIGIRR antibody
      • Single Ig IL 1 related receptor antibody
      • Single Ig IL-1-related receptor antibody
      • Single Ig IL-1R-related molecule antibody
      • Single Ig IL1R Related Molecule antibody
      • Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody
      • Single immunoglobulin and toll interleukin 1 receptor domain antibody
      • Single immunoglobulin domain containing IL1R related protein antibody
      • Single immunoglobulin domain IL1R1 related antibody
      • Single immunoglobulin domain-containing IL1R-related protein antibody
      • TIR 8 antibody
      • TIR8 antibody
      • Toll/interleukin 1 receptor 8 antibody
      • Toll/interleukin-1 receptor 8 antibody
      see all

    Images

    • Anti-SIGIRR antibody [EPR12638] (ab177937) at 1/1000 dilution + Fetal kidney lysate at 10 µg

      Predicted band size: 46 kDa

    References

    ab177937 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab177937.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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