Key features and details
- Mouse monoclonal [MM0547-10D5] to SIGIRR
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein G purified
Purification notesThe IgG fraction of culture supernatant was purified by protein G affinity chromatography and filtered through a 0.2 µm filter.
Our Abpromise guarantee covers the use of ab90253 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 46 kDa.|
FunctionActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificityMainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similaritiesBelongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.
- Information by UniProt
- Ig IL1 related receptor antibody
- MGC110992 antibody
- SIGIR_HUMAN antibody
ab90253 has not yet been referenced specifically in any publications.