Overview

  • Product name

  • Description

    Rabbit polyclonal to Siglec 7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ELISAmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to amino acids from the N terminal region of Human Siglec 7.

  • Positive control

    • Human tonsil tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab133388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 51 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA 1/1000.

Target

  • Function

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
  • Tissue specificity

    Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications

    Tyrosine phosphorylated.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Adhesion inhibitory receptor molecule 1 antibody
    • Adhesion inhibitory receptor molecule 1, siglec 7 antibody
    • AIRM 1 antibody
    • AIRM-1 antibody
    • AIRM1 antibody
    • CD328 antibody
    • CD328 antigen antibody
    • CDw328 antibody
    • D siglec antibody
    • D-siglec antibody
    • HLDA 8 antibody
    • p75 antibody
    • p75/AIRM1 antibody
    • QA79 antibody
    • QA79 membrane protein antibody
    • Sialic acid binding Ig like lectin 7 antibody
    • Sialic acid binding immunoglobulin like lectin 7 antibody
    • Sialic acid-binding Ig-like lectin 7 antibody
    • SIGL7_HUMAN antibody
    • Siglec-7 antibody
    • SIGLEC19P antibody
    • SIGLEC7 antibody
    • SIGLECP2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin embedded Human tonsil tissue labelling Siglec 7 with ab133388 at 10 µg/ml. Followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab133388 has not yet been referenced specifically in any publications.

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