Overview

  • Product name

    Anti-SIGLEC10 antibody - C-terminal
  • Description

    Rabbit polyclonal to SIGLEC10 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human SIGLEC10 (C terminal). NP_149121.
    Database link: Q96LC7

  • Positive control

    • Human brain tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • Tissue specificity

    Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications

    Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • mSiglec G antibody
    • PRO940 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • Sialic acid binding Ig like lectin 10 antibody
    • sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody
    • sialic acid binding Ig like lectin G antibody
    • Sialic acid binding Immunoglobulin like lectin 10 antibody
    • Sialic acid-binding Ig-like lectin 10 antibody
    • SIG10_HUMAN antibody
    • SIGLEC 10 antibody
    • Siglec G antibody
    • siglec like gene 2 antibody
    • Siglec like protein 2 antibody
    • Siglec like protein 2 antibody
    • Siglec-10 antibody
    • Siglec-like protein 2 antibody
    • SIGLEC10 antibody
    • Siglecg antibody
    • SLG2 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling SIGLEC10 with ab198724 at 1/25 dilution.

References

ab198724 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab198724.
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