Key features and details
- Rabbit polyclonal to SIGLEC11
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SIGLEC11 antibody
See all SIGLEC11 primary antibodies
DescriptionRabbit polyclonal to SIGLEC11
SpecificitySpecific to Human SIGLEC11, does not cross react with SIGLEC10.
Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
Species reactivityReacts with: Human
18 amino acid peptide from near the carboxy terminus of Human SIGLEC11 (NP_443116).
- HepG2 cell lysate Human liver tissue
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at 4°C (stable for up to 12 months).
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab106390 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 76 kDa.|
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Tissue specificityExpressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
modificationsPhosphorylated on tyrosine residues.
- Information by UniProt
- sialic acid binding Ig like lectin 11 antibody
- sialic acid binding lectin 11 antibody
- Sialic acid-binding Ig-like lectin 11 antibody
ab106390 at 5µg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.
Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.
Anti-SIGLEC11 antibody (ab106390) at 1 µg/ml + HepG2 cell lysate at 15 µg
Predicted band size: 76 kDa
ab106390 has not yet been referenced specifically in any publications.