Overview

  • Product name
    Anti-SIGLEC11 antibody [EPR8506(2)]
    See all SIGLEC11 primary antibodies
  • Description
    Rabbit monoclonal [EPR8506(2)] to SIGLEC11
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human SIGLEC11 (UniProt Q96RL6).

  • Positive control
    • Human fetal brain and fetal liver lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab157187 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 66 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IHC-P.
  • Target

    • Function
      Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
    • Tissue specificity
      Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
    • Sequence similarities
      Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Domain
      Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • Post-translational
      modifications
      Phosphorylated on tyrosine residues.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • sialic acid binding Ig like lectin 11 antibody
      • sialic acid binding lectin 11 antibody
      • Sialic acid-binding Ig-like lectin 11 antibody
      • Sialic acid-binding lectin 11 antibody
      • SIG11_HUMAN antibody
      • Siglec 11 antibody
      • Siglec-11 antibody
      • SIGLEC11 antibody
      see all

    Images

    • All lanes : Anti-SIGLEC11 antibody [EPR8506(2)] (ab157187) at 1/1000 dilution

      Lane 1 : Human fetal brain lysate
      Lane 2 : Human fetal liver lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 66 kDa

    References

    ab157187 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab157187.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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