Overview

  • Product name

  • Description

    Rabbit polyclonal to SIGLEC9
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human SIGLEC9 (internal sequence). (BC035365; The identity of the protein fusion partner is GST).
    Database link: Q9Y336

  • Positive control

    • Jurkat whole cell lysate (ab7899); Human thyroid cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 50 kDa.
IHC-P 1/25 - 1/100.

Target

  • Function

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Tissue specificity

    Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD329 antibody
    • CDw329 antibody
    • FOAP 9 antibody
    • OB binding protein like antibody
    • OBBP LIKE antibody
    • Protein FOAP 9 antibody
    • Protein FOAP-9 antibody
    • sialic acid binding Ig like lectin 9 antibody
    • Sialic acid-binding Ig-like lectin 9 antibody
    • Sialic acid-binding immunoglobulin like lectin 9 antibody
    • SIGL9_HUMAN antibody
    • Siglec 9 antibody
    • Siglec-9 antibody
    • SIGLEC9 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling SIGLEC9 with ab197981 at 1/30 dilution.

  • Anti-SIGLEC9 antibody (ab197981) at 1/350 dilution + Jurkat cell lysate at 50 µg

    Predicted band size: 50 kDa


    Exposure time: 30 seconds


    6% SDS-PAGE

References

ab197981 has not yet been referenced specifically in any publications.

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