Overview

  • Product name

    Anti-Sigma1-receptor antibody
    See all Sigma1-receptor primary antibodies
  • Description

    Rabbit polyclonal to Sigma1-receptor
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human, Zebrafish
    Predicted to work with: Mouse, Rat, Guinea pig, Cow, Rhesus monkey
  • Immunogen

    Recombinant fragment corresponding to Human Sigma1-receptor aa 8-223.
    Database link: Q99720

  • Positive control

    • 293T whole cell lysate; Human SW480 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab151288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 25 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
  • Tissue specificity

    Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells.
  • Involvement in disease

    Amyotrophic lateral sclerosis 16, juvenile
  • Sequence similarities

    Belongs to the ERG2 family.
  • Cellular localization

    Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > growth cone. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding.
  • Information by UniProt
  • Database links

  • Alternative names

    • Aging associated gene 8 protein antibody
    • Aging-associated gene 8 protein antibody
    • AL024364 antibody
    • hSigmaR1 antibody
    • mSigmaR1 antibody
    • opioid receptor, sigma 1 antibody
    • opioid receptor, sigma 1 isoform 1 antibody
    • RP23 167I12.6 antibody
    • SGMR1_HUMAN antibody
    • SIG 1R antibody
    • SIG-1R antibody
    • Sigma 1-type opioid receptor antibody
    • Sigma non-opioid intracellular receptor 1 antibody
    • sigma1 receptor antibody
    • Sigma1-receptor antibody
    • Sigma1R antibody
    • Sigmar1 antibody
    • SR BP antibody
    • SR-BP antibody
    • SR31747 binding protein antibody
    • SR31747-binding protein antibody
    • SRBP antibody
    see all

Images

  • All lanes : Anti-Sigma1-receptor antibody (ab151288) at 1/500 dilution

    Lane 1 : WT 293T cell extracts
    Lane 2 : Sigma1-receptor Knockout 293T cell extracts

    Lysates/proteins at 30 µg per lane.

    Secondary
    All lanes : HRP-conjugated anti-rabbit IgG

    Predicted band size: 25 kDa

  • Immunohistochemical analysis of paraffin-embedded Human SW480 xenograft labeling Sigma1-receptor with ab151288 at 1/100 dilution.

  • Anti-Sigma1-receptor antibody (ab151288) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 25 kDa



    12% SDS PAGE

References

ab151288 has not yet been referenced specifically in any publications.

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