Anti-Sigma1-receptor antibody - C-terminal (ab53852)
Key features and details
- Rabbit polyclonal to Sigma1-receptor - C-terminal
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
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Overview
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Product name
Anti-Sigma1-receptor antibody - C-terminal
See all Sigma1-receptor primary antibodies -
Description
Rabbit polyclonal to Sigma1-receptor - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Cow, Dog, Human, Mink -
Immunogen
Synthetic peptide corresponding to Rat Sigma1-receptor (C terminal).
Database link: Q99720 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab53852 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).
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Notes |
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WB
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa). |
Target
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Function
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. -
Tissue specificity
Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. -
Involvement in disease
Amyotrophic lateral sclerosis 16, juvenile -
Sequence similarities
Belongs to the ERG2 family. -
Cellular localization
Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > growth cone. Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. - Information by UniProt
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Database links
- Entrez Gene: 538903 Cow
- Entrez Gene: 481587 Dog
- Entrez Gene: 10280 Human
- Entrez Gene: 18391 Mouse
- Entrez Gene: 29336 Rat
- Omim: 601978 Human
- SwissProt: Q58DH7 Cow
- SwissProt: Q99720 Human
see all -
Alternative names
- Aging associated gene 8 protein antibody
- Aging-associated gene 8 protein antibody
- AL024364 antibody
see all
Images
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All lanes : Anti-Sigma1-receptor antibody - C-terminal (ab53852) at 2 µg/ml
Lane 1 : Mouse brain homogenate
Lane 2 : Rat liver homogenate
Lane 3 : Rat brain homogenate
Predicted band size: 25 kDa
Observed band size: 25 kDa
Additional bands at: 75 kDa. We are unsure as to the identity of these extra bands.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (32)
ab53852 has been referenced in 32 publications.
- Shin SM et al. Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain. Gene Ther 29:1-15 (2022). PubMed: 32424233
- Song L et al. Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat Cardiovasc Res 1:142-156 (2022). PubMed: 36051854
- Szabó Í et al. N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Neuropharmacology 192:108612 (2021). PubMed: 34023338
- Carpio MA et al. BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites. Cell Rep 34:108827 (2021). PubMed: 33691099
- Qu J et al. Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment. Oxid Med Cell Longev 2021:8836818 (2021). PubMed: 33488945