Anti-SIK1 antibody (ab217809)

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Overview

  • Product name

    Anti-SIK1 antibody
    See all SIK1 primary antibodies

  • Description

    Rabbit polyclonal to SIK1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Human

  • Immunogen

    Synthetic peptide within Human SIK1 aa 40-90 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    VVKLARHRVTK TQVAIKIIDK TRLDSSNLEK IYREVQLMKL LNHPHIIKLY


    Database link: P57059

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • WB: Mouse adrenal lysate.

  • General notes

    This product was previously labelled as Snf1lk/SIK-1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab217809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 85 kDa.

Target

  • Function

    Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.

  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.

  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.

  • Cellular localization

    Cytoplasm. Nucleus. Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.
  • Information by UniProt

  • Database links

    • Alternative names

      • KID2 antibody
      • MSK antibody
      • myocardial SNF1 like kinase antibody
      • QIK antibody
      • Qin-induced kinase antibody
      • Salt inducible kinase 1 antibody
      • Salt-inducible protein kinase 1 antibody
      • Serine threonine protein kinase SNF1 like kinase 1 antibody
      • Serine threonine protein kinase SNF1LK antibody
      • Serine/threonine-protein kinase SIK1 antibody
      • Serine/threonine-protein kinase SNF1-like kinase 1 antibody
      • Serine/threonine-protein kinase SNF1LK antibody
      • SIK-1 antibody
      • SIK1 antibody
      • SIK1_HUMAN antibody
      • SNF1 like kinase antibody
      • Snf1lk antibody
      see all

    Images

    • Western blot - Anti-SIK1 antibody (ab217809)
      Western blot - Anti-SIK1 antibody (ab217809)
      Anti-SIK1 antibody (ab217809) at 1/300 dilution + mouse adrenal lysate

      Secondary
      Goat anti-rabbit IgG antibody (H+L), HRP at 1/5000 dilution

      Predicted band size: 85 kDa

    References

    This product has been referenced in:

    • Hong B  et al. Activation of the LKB1-SIK1 signaling pathway inhibits the TGF-ß-mediated epithelial-mesenchymal transition and apoptosis resistance of ovarian carcinoma cells. Mol Med Rep 17:2837-2844 (2018). Read more (PubMed: 29257268) »
    See 1 Publication for this product

    Publishing research using ab217809? Please let us know so that we can cite the reference in this datasheet.

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