Overview

  • Product name

    Anti-SIK2 antibody [S15G10]
    See all SIK2 primary antibodies
  • Description

    Mouse monoclonal [S15G10] to SIK2
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IP, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human SIK2. (BAA34501.3)

  • Positive control

    • IHC-P: Human Pancreas tissue; WB: HeLa; ICC/IF: Nocodazole treated HeLa;
  • General notes

     This product was previously labelled as Snf1lk2, Snf1lk+Snf1lk2+SIK3

     

Properties

Applications

Our Abpromise guarantee covers the use of ab115567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250. Predicted molecular weight: 104 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/400.

Target

  • Function

    Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp434K1115 antibody
    • EC 2.7.11.1 antibody
    • KIAA0781 antibody
    • LOH11CR1I antibody
    • QIK antibody
    • Qin induced kinase antibody
    • Qin-induced kinase antibody
    • Salt inducible kinase 2 antibody
    • Salt inducible protein kinase 2 antibody
    • Salt inducible serine/threonine kinase 2 antibody
    • Salt-inducible protein kinase 2 antibody
    • Serine/threonine protein kinase SIK2 antibody
    • Serine/threonine protein kinase SNF1 like kinase 2 antibody
    • Serine/threonine-protein kinase SIK2 antibody
    • Serine/threonine-protein kinase SNF1-like kinase 2 antibody
    • SIK 2 antibody
    • SIK-2 antibody
    • SIK2 antibody
    • SIK2_HUMAN antibody
    • SNF1 like kinase antibody
    • SNF1 like kinase 2 antibody
    • SNF1LK2 antibody
    see all

Images

  • Anti-SIK2 antibody [S15G10] (ab115567) + HeLa cell lysate

    Predicted band size: 104 kDa

  • Overnight nocodazole treated HeLa cells stained with purified ab115567, followed by Cy3 conjugated Goat anti-mouse IgG and DAPI.

  • ab115567, at 10µg/ml, staining SIK2 in Formalin-fixed, Paraffin-embedded Human Pancreas tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115567 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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