Sildenafil citrate, phosphodiesterase 5 (PDE5) inhibitor (ab141965)

Overview

  • Product name

    Sildenafil citrate, phosphodiesterase 5 (PDE5) inhibitor
  • Description

    Potent, orally active phosphodiesterase 5 (PDE5) inhibitor
  • Biological description

    Potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC50 = 4 nM). Various pharmacological effects in vivo.
  • Purity

    > 99%
  • CAS Number

    171599-83-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one citrate
  • Molecular weight

    666.70
  • Molecular formula

    C22H30N6O4S.C6H8O7
  • PubChem identifier

    62853
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
  • Source

    Synthetic

Associated products

References

This product has been referenced in:

  • Moustafa YM  et al. Sildenafil citrate protects against gastric mucosal damage induced by indomethacin in rats. Eur Rev Med Pharmacol Sci 17:179-88 (2013). Read more (PubMed: 23377805) »
  • Yildirim A  et al. Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. Pulm Pharmacol Ther 23:215-21 (2010). Read more (PubMed: 19945540) »
  • Ballard SA  et al. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 159:2164-71 (1998). Read more (PubMed: 9598563) »

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