Overview

  • Product name

    Silymarin, estrogenic agent
  • Description

    Estrogenic, antioxidant and apoptotic agent
  • Alternative names

    • Silibinin
    • Silybinin
  • Biological description

    Estrogenic, antioxidant, antiviral and apoptotic agent. Flavonolignan mixture of silibinin (ab143149) silydianin, silycristin, isosilybin A, isosilybin B, isosilycristin, and taxifolin. Shows neuroprotective, hepatoprotective and antiproliferative effects in vivo. Orally active.

  • Purity

    > 70%
  • CAS Number

    65666-07-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3R)-3,5,7-Trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
  • Molecular weight

    482.44
  • Molecular formula

    C25H22O10
  • PubChem identifier

    1548994
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Atawia RT  et al. Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats. Toxicol Lett 219:160-9 (2013). Read more (PubMed: 23500659) »
  • Muley MM  et al. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Life Sci 93:51-7 (2013). Read more (PubMed: 23743171) »
  • Hawas UW  et al. A new flavonoid C-glycoside from Solanum elaeagnifolium with hepatoprotective and curative activities against paracetamol-induced liver injury in mice. Z Naturforsch C 68:19-28 (0). Read more (PubMed: 23659169) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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