Key features and details
- Rabbit polyclonal to SIMPL
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SIMPL antibody
See all SIMPL primary antibodies
DescriptionRabbit polyclonal to SIMPL
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Monkey
Recombinant fragment within Human SIMPL aa 1-255. The exact sequence is proprietary.
Database link: Q5VVH5
- Human testis tissue.
This product was previously labelled as IRAK1BP1
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 89% Tris glycine, 10% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab190234 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 29 kDa.|
|IHC-P||Use a concentration of 10 µg/ml.|
FunctionComponent of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
Sequence similaritiesBelongs to the IRAK1BP1 family.
DomainThe intrinsically disordered region interacts with HSPA1 and HSPA8.
modificationsPhosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- ActA binding protein 3 antibody
- AIP70 antibody
- IKBP1_HUMAN antibody
ab190234 has been referenced in 1 publication.
- Chen X et al. Downregulation of microRNA-146a inhibits ovarian granulosa cell apoptosis by simultaneously targeting interleukin-1 receptor-associated kinase and tumor necrosis factor receptor-associated factor 6. Mol Med Rep 12:5155-62 (2015). PubMed: 26151128