Overview

  • Product name

  • Description

    Rabbit polyclonal to SIMPL
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Recombinant fragment within Human SIMPL (internal sequence). The exact sequence is proprietary.
    Database link: Q5VVH5

  • Positive control

    • IHC-P: Human placenta, mouse kidney and rat intestine tissue.
  • General notes

     This product was previously labelled as IRAK1BP1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab228579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.

Target

  • Function

    Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
  • Sequence similarities

    Belongs to the IRAK1BP1 family.
  • Domain

    The intrinsically disordered region interacts with HSPA1 and HSPA8.
  • Post-translational
    modifications

    Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ActA binding protein 3 antibody
    • AIP70 antibody
    • IKBP1_HUMAN antibody
    • Interleukin 1 receptor associated kinase 1 binding protein 1 antibody
    • Interleukin-1 receptor-associated kinase 1-binding protein 1 antibody
    • IRAK1-binding protein 1 antibody
    • IRAK1BP1 antibody
    • Signaling molecule that associates with Pelle-like kinase antibody
    • SIMPL antibody
    see all

Images

  • Paraffin-embedded human placenta tissue stained for SIMPL with ab228579 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded rat intestine tissue stained for SIMPL with ab228579 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded mouse kidney tissue stained for SIMPL with ab228579 at 1/500 dilution in immunohistochemical analysis.

References

ab228579 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab228579.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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