Anti-SIRT6 antibody - ChIP Grade (ab62739)

Rabbit polyclonal SIRT6 antibody. Validated in WB, Flow Cyt, ChIP, IHC, ICC/IF, CHIPseq and tested in Mouse, Rat, Chicken, Human. Cited in 29 publication(s). Independently reviewed in 14 review(s).

Publishing research using ab62739? Please let us know so that we can cite the reference in this datasheet.

ab62739 has been referenced in 35 publications.

  • Xue W  et al. FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma. Oncol Rep 41:1404-1414 (2019). PubMed: 30483801
  • Hu M  et al. Sirtuin 6 Attenuates Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Suppressing Ori-Lyt Activity and Expression of RTA. J Virol 93:N/A (2019). PubMed: 30651359
  • Gao Y  et al. SIRT6 inhibits proliferation and invasion in osteosarcoma cells by targeting N-cadherin. Oncol Lett 17:1237-1244 (2019). PubMed: 30655890
  • Naciri I  et al. Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Nucleic Acids Res 47:3407-3421 (2019). PubMed: 30753595
  • D'Onofrio N  et al. Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients. Int J Mol Sci 20:N/A (2019). PubMed: 30845774
  • Ye H & Duan M Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells. Cancer Manag Res 10:5145-5156 (2018). PubMed: 30464613
  • Santos-Barriopedro I  et al. SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-?B pathway. Nat Commun 9:101 (2018). WB, ChIP ; Human . PubMed: 29317652
  • Qian M  et al. Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Elife 7:N/A (2018). PubMed: 29717979
  • Strub T  et al. SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. Nat Commun 9:3440 (2018). PubMed: 30143629
  • Hong JY  et al. Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes. Arch Biochem Biophys 659:1-12 (2018). PubMed: 30243709
  • Liu B DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications. Biochem Biophys Res Commun 507:286-290 (2018). PubMed: 30448059
  • Chen W  et al. Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice. Cell Rep 18:2880-2892 (2017). WB . PubMed: 28329681
  • Lin H  et al. Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway. FEBS Open Bio 7:1291-1301 (2017). PubMed: 28904859
  • Samant SA  et al. The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. Sci Rep 7:11877 (2017). PubMed: 28928419
  • Diani-Moore S  et al. NAD(+) loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD(+) repletion. Sci Rep 7:2268 (2017). WB . PubMed: 28536482
  • Ioris RM  et al. SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell Rep 18:1858-1868 (2017). ChIP . PubMed: 28228253
  • Zhang ZQ  et al. Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice. Sci Rep 6:23912 (2016). ChIP, WB . PubMed: 27045575
  • Anderson JG  et al. Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab 4:846-56 (2015). PubMed: 26629408
  • Kim TH  et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta 1850:401-10 (2015). PubMed: 25445714
  • Kugel S  et al. Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer. Cell Rep 13:479-88 (2015). WB, ChIP ; Mouse . PubMed: 26456828
  • Silberman DM  et al. SIRT6 is required for normal retinal function. PLoS One 9:e98831 (2014). WB ; Mouse . PubMed: 24896097
  • Van Meter M  et al. SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun 5:5011 (2014). PubMed: 25247314
  • Yu W  et al. Short-term calorie restriction activates SIRT1-4 and -7 in cardiomyocytes in vivo and in vitro. Mol Med Rep 9:1218-24 (2014). PubMed: 24535021
  • Simeoni F  et al. Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling. Sci Rep 3:3085 (2013). Human . PubMed: 24169447
  • Tao R  et al. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 54:2745-53 (2013). Mouse . PubMed: 23881913
  • Rottiers V  et al. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Sci Transl Med 5:212ra162 (2013). WB . PubMed: 24259050
  • Toiber D  et al. SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol Cell 51:454-68 (2013). WB, IP ; Mouse . PubMed: 23911928
  • Mao Z  et al. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A 109:11800-5 (2012). WB . PubMed: 22753495
  • Sebastián C  et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 151:1185-99 (2012). WB ; Mouse . PubMed: 23217706
  • Yang SJ  et al. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. PLoS One 6:e17057 (2011). WB ; Rat . PubMed: 21373642
  • Tao R  et al. Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem 286:14681-90 (2011). WB ; Human . PubMed: 21388966
  • Ram O  et al. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell 147:1628-39 (2011). WB, CHIPseq ; Human . PubMed: 22196736
  • Wang KC  et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 472:120-4 (2011). PubMed: 21423168
  • Zhong L  et al. The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha. Cell 140:280-293 (2010). WB ; Mouse . PubMed: 20141841
  • Schwer B  et al. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A : (2010). WB ; Mouse . PubMed: 21098266

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