• Product name

    Anti-SIRT7 antibody [1E2B2]
    See all SIRT7 primary antibodies
  • Description

    Mouse monoclonal [1E2B2] to SIRT7
  • Host species

  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human SIRT7 aa 1-105. Expressed in E. coli.
    Database link: Q9NRC8

  • Positive control

    • WB: SIRT7 (amino acids: 1-105)-hIgGFc transfected HEK-293 cell lysate; Human recombinant SIRT7 (amino acids: 1-105) protein. Flow Cytometry: HeLa cells.



Our Abpromise guarantee covers the use of ab234088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500.
Flow Cyt 1/200 - 1/400.


  • Function

    NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
  • Sequence similarities

    Belongs to the sirtuin family. Class IV subfamily.
    Contains 1 deacetylase sirtuin-type domain.
  • Post-translational

    Phosphorylated during mitosis.
  • Cellular localization

    Cytoplasm. Nucleus, nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
  • Information by UniProt
  • Database links

  • Alternative names

    • NAD dependent deacetylase sirtuin 7 antibody
    • NAD dependent protein deacetylase sirtuin 7 antibody
    • NAD-dependent protein deacetylase sirtuin-7 antibody
    • Regulatory protein SIR2 homolog 7 antibody
    • Silent mating type information regulation 2 homolog antibody
    • Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody
    • SIR2 L7 antibody
    • SIR2 like protein 7 antibody
    • Sir2 related protein type 7 antibody
    • SIR2-like protein 7 antibody
    • SIR2L 7 antibody
    • SIR2L7 antibody
    • SIR7_HUMAN antibody
    • SIRT 7 antibody
    • SIRT7 antibody
    • Sirtuin 7 antibody
    • Sirtuin type 7 antibody
    • Sirtuin7 antibody
    see all


  • Flow Cytometry analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cells, labeling SIRT7 with ab234088 at 1/200 dilution (green) compared to a negative control (red).

  • All lanes : Anti-SIRT7 antibody [1E2B2] (ab234088) at 1/100 dilution

    Lane 1 : HEK-293 (human epithelial cell line from embryonic kidney) cell lysate
    Lane 2 : SIRT7 (amino acids: 1-105)-hIgGFc transfected HEK-293 cell lysate
  • Anti-SIRT7 antibody [1E2B2] (ab234088) at 1/100 dilution + Human recombinant SIRT7 (amino acids: 1-105) protein

    Expected recombinant MW is 38 kDa


ab234088 has not yet been referenced specifically in any publications.

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