- References (1)
Product nameSirtinol, Sirtuin deacetylase inhibitor
DescriptionSelective sirtuin deacetylase inhibitor
Biological descriptionSelective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively). No effect on HDAC1. Cell-permeable.
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Class III / Sir2 class
This product has been referenced in:
- Jung-Hynes B et al. Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem 284:3823-32 (2009). Read more (PubMed: 19075016) »
- Ota H et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25:176-85 (2006). Read more (PubMed: 16170353) »
- Mai A et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem 48:7789-95 (2005). Read more (PubMed: 16302818) »
- Grozinger CM et al. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276:38837-43 (2001). Read more (PubMed: 11483616) »