Overview

  • Product name

    Sirtinol, Sirtuin deacetylase inhibitor
  • Description

    Selective sirtuin deacetylase inhibitor
  • Biological description

    Selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively). No effect on HDAC1. Cell-permeable.
  • Purity

    > 99%
  • CAS Number

    410536-97-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jung-Hynes B  et al. Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem 284:3823-32 (2009). Read more (PubMed: 19075016) »
  • Ota H  et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25:176-85 (2006). Read more (PubMed: 16170353) »
  • Mai A  et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem 48:7789-95 (2005). Read more (PubMed: 16302818) »
  • Grozinger CM  et al. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276:38837-43 (2001). Read more (PubMed: 11483616) »
See 1 Publication for this product

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