Sitaxentan sodium, endothelin A receptor antagonist (ab144565)

Overview

  • Product name

    Sitaxentan sodium, endothelin A receptor antagonist
  • Description

    Highly potent, selective and competitive endothelin A receptor antagonist
  • Biological description

    Highly potent, selective and competitive endothelin A receptor antagonist (IC50 = 1.4 nM). Orally active. Antihypertensive agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    210421-74-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(4-Chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-2H-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide sodium salt
  • Molecular weight

    476.88
  • Molecular formula

    C18H14ClN2NaO6S2
  • PubChem identifier

    11477084
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)[N-]C4=C(C(=NO4)C)Cl)OCO2.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tilton RG  et al. Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist. Pulm Pharmacol Ther 13:87-97 (2000). Read more (PubMed: 10799286) »
  • Wu C  et al. Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist. J Med Chem 40:1690-7 (1997). Read more (PubMed: 9171878) »

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