Overview

  • Product name

    Sivelestat, neutrophil elastase inhibitor
  • Description

    Potent, selective, substrate competitive neutrophil elastase inhibitor
  • Biological description

    Potent, selective, substrate competitive neutrophil elastase inhibitor (IC50 values are 19-49 nM and 5.6 μM for leukocyte and pancreas elastase respectively). Suppresses neutrophil-induced capillary permeability and leukocyte kinetics. Active in vivo.
  • CAS Number

    127373-66-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Masood A  et al. Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats. Am J Physiol Lung Cell Mol Physiol 309:L53-62 (2015). Read more (PubMed: 26136527) »
  • Muley MM  et al. Neutrophil Elastase-Induced Inflammation and Pain in Mouse Knee Joints via Activation of Proteinase Activated Receptor-2. Br J Pharmacol : (2015). Read more (PubMed: 26140667) »
  • Kim DH  et al. Effect of a neutrophil elastase inhibitor on ventilator-induced lung injury in rats. J Thorac Dis 6:1681-9 (2014). Read more (PubMed: 25589960) »

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