Sivelestat sodium tetrahydrate, Neutrophil elastase inhibitor (ab142369)

Overview

  • Product name

    Sivelestat sodium tetrahydrate, Neutrophil elastase inhibitor
  • Description

    Neutrophil elastase inhibitor
  • Biological description

    Neutrophil elastase inhibitor. Anti-inflammatory agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    201677-61-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Sodium 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate tetrahydrate

  • Molecular weight

    528.51
  • Molecular formula

    C20H21N2NaO7S.4H2O
  • PubChem identifier

    23663985
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    PLHREJBSQUSUCW-UHFFFAOYSA-M
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hagiwara S  et al. Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB. Inflamm Res 58:198-203 (2009). Read more (PubMed: 19169649) »
  • Hagio T  et al. Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. Eur J Pharmacol 426:131-8 (2001). Read more (PubMed: 11525781) »
  • Tai S  et al. Effect of human neutrophil elastase on tracheal mucociliary transport in anesthetized quails. Jpn J Pharmacol 75:439-42 (1997). Read more (PubMed: 9469651) »

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