Key features and details
- Mouse polyclonal to Six3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Six3 antibody
See all Six3 primary antibodies
DescriptionMouse polyclonal to Six3
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Full length protein corresponding to Human Six3 aa 1-332.
MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGG GNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLE ETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYH ILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLP RTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQV GNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTA ASPTTSVSSLTERADTGTSILSVTSSDSECDV
Database link: AAI53027.1
- Six3 transfected 293T cell line lysate
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Constituent: 100% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab172131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa.|
FunctionMay be involved in visual system development.
Involvement in diseaseDefects in SIX3 are the cause of holoprosencephaly type 2 (HPE2) [MIM:157170]. Holoprosencephaly (HPE) [MIM:236100] is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Sequence similaritiesBelongs to the SIX/Sine oculis homeobox family.
Contains 1 homeobox DNA-binding domain.
- Information by UniProt
- Homeobox protein SIX3 antibody
- HPE2 antibody
- Sine oculis homeobox homolog 3 antibody
ab172131 has been referenced in 1 publication.
- Li Y et al. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells. J Biol Chem 292:19590-19604 (2017). PubMed: 28972157