SKF 83566 hydrobromide, D1 receptor antagonist (ab141146)

Overview

  • Product name

    SKF 83566 hydrobromide, D1 receptor antagonist
  • Description

    Potent, selective D1 receptor antagonist
  • Biological description

    Potent, selective D1 receptor antagonist (Ki = 0.4 nM). Centrally active following systemic administration. Various neurological effects in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    108179-91-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
  • Molecular weight

    413.15
  • Molecular formula

    C17H18BrNO.HBr
  • PubChem identifier

    23581817
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM, in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Br.Brc1cc2CCN(C)CC(c2cc1O)c3ccccc3
  • Source

    Synthetic

References

This product has been referenced in:

  • Takano K  et al. Extracellular superoxide dismutase induced by dopamine in cultured astrocytes. Neurochem Res 38:32-41 (2013). Read more (PubMed: 22983620) »
  • McLaughlin PJ  et al. Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists. Pharmacol Biochem Behav 96:75-81 (2010). Read more (PubMed: 20403373) »
  • Fritts ME  et al. Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride. Pharmacol Biochem Behav 60:639-44 (1998). Read more (PubMed: 9678647) »
  • Sunahara RK  et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature 350:614-9 (1991). Read more (PubMed: 1826762) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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