SKI-I, Sphingosine Kinase Inhibitor (ab142209)
Key features and details
- Specific non-lipid sphingosine kinase (SK) inhibitor. Cell-permeable.
- CAS Number: 306301-68-8
- Purity: > 90%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SKI-I, Sphingosine Kinase Inhibitor -
Description
Specific non-lipid sphingosine kinase (SK) inhibitor. Cell-permeable. -
Purity
> 90% -
CAS Number
306301-68-8 -
Chemical structure
Properties
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Chemical name
5-(2-Naphthalenyl)-1H-pyrazole-3-carboxylic acid 2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide -
Molecular weight
406.44 -
Molecular formula
C25H18N4O2 -
PubChem identifier
137269090 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1C(NNC1C(=O)N/N=C/C2=C(C=CC3=CC=CC=C32)O)C4=CC5=CC=CC=C5C=C4 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab142209 has been referenced in 3 publications.
- Terao R et al. Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration. Int J Mol Sci 20:N/A (2019). PubMed: 31357484
- Mrad M et al. Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma. Oncotarget 7:71873-71886 (2016). PubMed: 27708249
- Kassmer SH et al. Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. Nat Commun 6:8565 (2015). PubMed: 26456232