Overview

  • Product name

    SKI-I, Sphingosine Kinase Inhibitor
  • Description

    Specific non-lipid sphingosine kinase (SK) inhibitor. Cell-permeable.
  • Biological description

    Specific non-lipid sphingosine kinase (SK) inhibitor. Inhibits SK1 and SK2. Inhibits sphingosine 1-phosphate (S1P) production and pro-apoptotic. Induces autophagy. Cell permeable and active in vivo and in vitro.
  • Purity

    > 90%
  • CAS Number

    306301-68-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-(2-Naphthalenyl)-1H-pyrazole-3-carboxylic acid 2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
  • Molecular weight

    406.44
  • Molecular formula

    C25H18N4O2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Unstable; make up solutions fresh and use immediately.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc5ccc1ccccc1c5C=NNC(=O)c2cc(nn2)c3ccc4ccccc4c3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Burri DJ  et al. Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. J Virol 86:4935-46 (2012). Read more (PubMed: 22357276) »
  • Young MM  et al. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem 287:12455-68 (2012). Read more (PubMed: 22362782) »
  • Sharma AK  et al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem 45:4149-56 (2010). Read more (PubMed: 20598402) »
See 1 Publication for this product

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