Overview

  • Product name

    Skyrin, glucagon receptor antagonist
  • Description

    Selective glucagon receptor antagonist
  • Biological description

    Selective glucagon receptor antagonist. Inhibits glucose output in hepatocytes (IC50 = 56 μM). Shows inhibitory effects on Na+, K+ activated ATPase activity in rat brain microsomes and cancer cell growth.
  • Purity

    > 97%
  • CAS Number

    602-06-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,4,5-Trihydroxy-7-methyl-1-(2,4,5-trihydroxy-7-methyl-9,10-dioxoanthracen-1-yl)anthracene-9,10-dione
  • Molecular weight

    538.46
  • Molecular formula

    C30H18O10
  • PubChem identifier

    73071
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=C2C(=C1)C(=O)C3=C(C(=CC(=C3C2=O)O)O)C4=C5C(=C(C=C4O)O)C(=O)C6=C(C=C(C=C6C5=O)C)O)O
  • Source

    Talaromyces sp.

  • Research areas

References

This product has been referenced in:

  • Parker JC  et al. Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes. Diabetes 49:2079-86 (2000). Read more (PubMed: 11118010) »
  • Ueno Y  et al. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Nat Toxins 3:129-37 (1995). Read more (PubMed: 7648021) »
  • Kawai K  et al. A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp. Toxicol Lett 20:155-60 (1984). Read more (PubMed: 6320499) »

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