SL 327, MEK inhibitor (ab120082)
Overview
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Product name
SL 327, MEK inhibitor -
Description
MEK inhibitor -
Biological description
Centrally active, brain penetrant selective MEK1 and MEK2 inhibitor (IC50 values in in vitro assays are 0.18 and 0.22 μM, respectively). -
Purity
> 99% -
CAS Number
305350-87-2 -
Chemical structure
Properties
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Chemical name
α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile -
Molecular weight
335.34 -
Molecular formula
C16H12F3N3S -
PubChem identifier
9549284 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N/C(Sc1ccc(N)cc1)=C(/[N+]#[C-])c2ccccc2C(F)(F)F -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References
ab120082 has been referenced in 7 publications.
- Li X & Wolf ME Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. Eur J Neurosci 34:190-8 (2011). PubMed: 21692887
- Groblewski PA et al. Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice. Behav Brain Res 217:399-407 (2011). PubMed: 21074569
- Knapp DJ et al. Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety. Brain Behav Immun 25 Suppl 1:S146-54 (2011). PubMed: 21377524
- Martín F et al. Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. Br J Pharmacol 163:857-75 (2011). PubMed: 21615389
- Almela P et al. Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. J Pharmacol Exp Ther 330:771-82 (2009). PubMed: 19567779
- Lindgren HS et al. Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. Neuropsychopharmacology 34:2477-88 (2009). PubMed: 19606087
- Almela P et al. The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. Br J Pharmacol 155:73-83 (2008). PubMed: 18536752
