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    sl-327-mek-inhibitor-ab120082.pdf

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Signal Transduction Protein Phosphorylation Tyrosine Kinases Other
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SL 327, MEK inhibitor (ab120082)

  • Datasheet
  • SDS
  • COA
Submit a review Q&A (2)References (7)

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Chemical Structure - SL 327, MEK inhibitor (ab120082)

    Key features and details

    • MEK inhibitor
    • CAS Number: 305350-87-2
    • Soluble in DMSO to 100 mM and in ethanol to 100 mM (with heating)
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      SL 327, MEK inhibitor
    • Description

      MEK inhibitor
    • Biological description

      Centrally active, brain penetrant selective MEK1 and MEK2 inhibitor (IC50 values in in vitro assays are 0.18 and 0.22 μM, respectively).

    • CAS Number

      305350-87-2
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
    • Molecular weight

      335.34
    • Molecular formula

      C16H12F3N3S
    • PubChem identifier

      9549284
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and in ethanol to 100 mM (with heating)
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      N/C(Sc1ccc(N)cc1)=C(/[N+]#[C-])c2ccccc2C(F)(F)F
    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Protein Phosphorylation
      • Tyrosine Kinases
      • Other
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • MAPK Pathway
      • Cancer
      • Signal transduction
      • Protein phosphorylation
      • Serine/threonine kinases
      • MAPK pathway
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    Images

    • Chemical Structure - SL 327, MEK inhibitor (ab120082)
      Chemical Structure - SL 327, MEK inhibitor (ab120082)
      2D chemical structure image of ab120082, SL 327, MEK inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (7)

    Publishing research using ab120082? Please let us know so that we can cite the reference in this datasheet.

    ab120082 has been referenced in 7 publications.

    • Li X & Wolf ME Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. Eur J Neurosci 34:190-8 (2011). PubMed: 21692887
    • Groblewski PA  et al. Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice. Behav Brain Res 217:399-407 (2011). PubMed: 21074569
    • Knapp DJ  et al. Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety. Brain Behav Immun 25 Suppl 1:S146-54 (2011). PubMed: 21377524
    • Martín F  et al. Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. Br J Pharmacol 163:857-75 (2011). PubMed: 21615389
    • Almela P  et al. Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. J Pharmacol Exp Ther 330:771-82 (2009). PubMed: 19567779
    • Lindgren HS  et al. Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. Neuropsychopharmacology 34:2477-88 (2009). PubMed: 19606087
    • Almela P  et al. The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. Br J Pharmacol 155:73-83 (2008). PubMed: 18536752

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-2 of 2 Abreviews or Q&A

    Question

    Hello,

    Please not Purity Requirement : >98% (Preferably HPLC) at least TLC. Please Send Certificate of Analysis.

    Thank you

    Read More

    Abcam community

    Verified customer

    Asked on Feb 28 2012

    Answer

    Here are certificates of analysis for the product and lot numbers you have been assigned for your orders (PO numer xxxxx, orders xxxxx and xxxxxx).


    If there are any problems please do let me know.

    Read More

    Abcam Scientific Support

    Answered on Feb 28 2012

    Question

    Hello,

    Please not Purity Requirement : >98% (Preferably HPLC) at least TLC. Please Send Certificate of Analysis.

    Thank you

    Read More

    Abcam community

    Verified customer

    Asked on Feb 27 2012

    Answer

    Thank you for contacting us.


    SL 327 (ab120082) and Kainic acid (ab120100) are both produced at >98% purity as determined by HPLC. I am checking which lots of these products have been assigned to you and then I will send the certificate of analysis for these lots.


    The TTX is produced at >96% purity as determined by HPLC but we have stocks of this which is of >98% purity and I will again make sure that these stocks are being allocated to you and send the certificate of analysis.


    In the meantime if you have any further questions please do not hesitate to ask.

    Read More

    Abcam Scientific Support

    Answered on Feb 27 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com

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