Overview

  • Product name
    Anti-SLAMF7/CS1 antibody [CAL6]
    See all SLAMF7/CS1 primary antibodies
  • Description
    Rabbit monoclonal [CAL6] to SLAMF7/CS1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human SLAMF7/CS1 aa 248-335.
    Database link: Q9NQ25

  • Positive control
    • IHC-P: SLAMF7/CS1 knock-in AD-293 cells; OPM2 xenograft.
  • General notes

     This product was previously labelled as SLAMF7

     

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.50
    Preservative: 0.05% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Purification notes
    Purity >99%
  • Clonality
    Monoclonal
  • Clone number
    CAL6
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab237729 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.1 µg/ml.

Boil tissue section in TRIS EDTA buffer for 24 minutes followed by cooling at room temperature for 30-45 minutes. Incubate with primary antibody for 75 minutes at room temperature. Slides must be washed in between steps. Rinse slides with TBS/0.05% Tween.

Target

  • Relevance
    SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
  • Cellular localization
    Membrane; Single-pass type I membrane protein.
  • Database links
  • Alternative names
    • 19A antibody
    • 19A24 protein antibody
    • CD 319 antibody
    • CD2 like receptor activating cytotoxic cells antibody
    • CD2 subset 1 antibody
    • CD319 antibody
    • CD319 antigen antibody
    • CRACC antibody
    • CS1 antibody
    • Membrane protein FOAP 12 antibody
    • Novel Ly9 antibody
    • Novel LY9 (lymphocyte antigen 9) like protein antibody
    • Protein 19A antibody
    • SLAM family member 7 antibody
    • SLAMF 7 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded OPM2 xenograft (Left panel), and NCI-N87 xenograft (Right panel) tissue stained for SLAMF7/CS1 using ab237729 at 0.1 µg/ml dilution in immunohistochemical analysis.

    Negative control: NCI-N87 xenograft (Right panel).

  • Formalin-fixed, paraffin-embedded multiple melanoma (Lambda, Left panel), and AD-293 SLAMF7/CS1 Knock-in (Right panel, positive control) tissue stained for SLAMF7/CS1 using ab237729 at 0.1 µg/ml dilution in immunohistochemical analysis.

References

ab237729 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab237729.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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