Anti-SLC10A2/ASBT antibody (ab203205)
Key features and details
- Rabbit polyclonal to SLC10A2/ASBT
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-SLC10A2/ASBT antibody
See all SLC10A2/ASBT primary antibodies -
Description
Rabbit polyclonal to SLC10A2/ASBT -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Human -
Immunogen
Synthetic peptide within Human SLC10A2/ASBT aa 150-250 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q12908 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab203205 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration.
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Notes |
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WB
Use at an assay dependent concentration. |
Target
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Function
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. -
Involvement in disease
Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM) [MIM:613291]. PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. -
Sequence similarities
Belongs to the sodium:bile acid symporter family. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 6555 Human
- Entrez Gene: 20494 Mouse
- Entrez Gene: 29500 Rat
- Omim: 601295 Human
- SwissProt: Q12908 Human
- SwissProt: P70172 Mouse
- SwissProt: Q62633 Rat
- Unigene: 194783 Human
see all -
Alternative names
- Apical sodium dependent bile acid transporter antibody
- Apical sodium- dependent bile acid transporter antibody
- Apical sodium-dependent bile acid transporter antibody
see all
Images
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All lanes : Anti-SLC10A2/ASBT antibody (ab203205) at 1/1000 dilution
Lane 1 : Mouse Kidney lysates
Lane 2 : Rat Kidney lysates
Secondary
All lanes : IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Observed band size: 38 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab203205 has been referenced in 5 publications.
- Liu X et al. MiR-203 is an anti-obese microRNA by targeting apical sodium-dependent bile acid transporter. iScience 25:104708 (2022). PubMed: 35856025
- Zhang Y et al. Ursodeoxycholic acid accelerates bile acid enterohepatic circulation. Br J Pharmacol 176:2848-2863 (2019). PubMed: 31077342
- Kim KS et al. Oral Nanoparticles Exhibit Specific High-Efficiency Intestinal Uptake and Lymphatic Transport. ACS Nano 12:8893-8900 (2018). PubMed: 30088412
- Xie G et al. Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure. EBioMedicine 37:294-306 (2018). PubMed: 30344125
- Zhu R et al. Pectin Penta-Oligogalacturonide Suppresses Intestinal Bile Acids Absorption and Downregulates the FXR-FGF15 Axis in High-Cholesterol Fed Mice. Lipids 52:489-498 (2017). Mouse . PubMed: 28474246