Key features and details
- Rabbit polyclonal to SLC12A3
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-SLC12A3 antibody
See all SLC12A3 primary antibodies
DescriptionRabbit polyclonal to SLC12A3
Tested applicationsSuitable for: ICC/IF, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
- Rat kidney tissue lysate.
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferPreservative: 0.007% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab95302 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Detects a band of approximately 160 kDa (predicted molecular weight: 111 kDa).|
FunctionElectrically silent transporter system. Mediates sodium and chloride reabsorption.
Tissue specificityPredominant in kidney.
Involvement in diseaseDefects in SLC12A3 are the cause of Gitelman syndrome (GS) [MIM:263800]. GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.
Sequence similaritiesBelongs to the SLC12A transporter family.
- Information by UniProt
- FLJ96318 antibody
- Na Cl cotransporter antibody
- Na Cl symporter antibody
ab95302 has been referenced in 2 publications.
- Zhang J et al. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Hum Mol Genet 24:4545-58 (2015). PubMed: 25994507
- Schumacher FR et al. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med 7:1285-306 (2015). PubMed: 26286618