Overview

  • Product name

    Anti-SLC12A6/KCC3 antibody
    See all SLC12A6/KCC3 primary antibodies
  • Description

    Rabbit polyclonal to SLC12A6/KCC3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human SLC12A6/KCC3 aa 60-190.
    Database link: Q9UHW9

  • Positive control

    • IHC-P: Human kidney tissue.
  • General notes

     This product was previously labelled as SLC12A6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab225990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
  • Tissue specificity

    Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).
  • Involvement in disease

    Agenesis of the corpus callosum, with peripheral neuropathy
  • Sequence similarities

    Belongs to the SLC12A transporter family.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Basolateral cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACCPN antibody
    • Electroneutral potassium-chloride cotransporter 3 antibody
    • Furosemide sensitive KCl cotransporter 3 antibody
    • Gaxp antibody
    • K-Cl cotransporter 3 antibody
    • KCC 3 antibody
    • KCC 3A antibody
    • KCC 3B antibody
    • KCC3 A antibody
    • KCC3 antibody
    • KCC3 B antibody
    • KCC3A antibody
    • KCC3B antibody
    • Potassium chloride cotransporter 3 antibody
    • Potassium chloride cotransporter KCC3a S3 antibody
    • S12A6_HUMAN antibody
    • SLC12 A6 antibody
    • SLC12A 6 antibody
    • SLC12A6 antibody
    • Solute carrier family 12 (potassium/chloride transporters), member 6 antibody
    • Solute carrier family 12 member 6 antibody
    • Solute carrier family 12, member 6 antibody
    see all

Images

  • Paraffin embedded human kidney tissue stained for SLC12A6/KCC3 with ab225990 (1/100 dilution) in immunohistochemical analysis.

References

ab225990 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab225990.
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