Overview

  • Product name

    Anti-SLC12A6/KCC3 antibody
    See all SLC12A6/KCC3 primary antibodies
  • Description

    Rabbit polyclonal to SLC12A6/KCC3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human SLC12A6/KCC3 aa 25-75. The exact sequence is proprietary. NP_598408.1
    Database link: Q9UHW9

  • Positive control

    • WB: HeLa, Jurkat and HEK-293T whole cell lysate.
  • General notes

     This product was previously labelled as SLC12A6

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: Tris citrate/phosphate

    pH 7 to 8
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Antibody was affinity purified using an epitope specific to SLC12A6/KCC3 immobilized on solid support
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab241348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000.

Target

  • Function

    Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
  • Tissue specificity

    Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).
  • Involvement in disease

    Agenesis of the corpus callosum, with peripheral neuropathy
  • Sequence similarities

    Belongs to the SLC12A transporter family.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Basolateral cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACCPN antibody
    • Electroneutral potassium-chloride cotransporter 3 antibody
    • Furosemide sensitive KCl cotransporter 3 antibody
    • Gaxp antibody
    • K-Cl cotransporter 3 antibody
    • KCC 3 antibody
    • KCC 3A antibody
    • KCC 3B antibody
    • KCC3 A antibody
    • KCC3 antibody
    • KCC3 B antibody
    • KCC3A antibody
    • KCC3B antibody
    • Potassium chloride cotransporter 3 antibody
    • Potassium chloride cotransporter KCC3a S3 antibody
    • S12A6_HUMAN antibody
    • SLC12 A6 antibody
    • SLC12A 6 antibody
    • SLC12A6 antibody
    • Solute carrier family 12 (potassium/chloride transporters), member 6 antibody
    • Solute carrier family 12 member 6 antibody
    • Solute carrier family 12, member 6 antibody
    see all

Images

  • All lanes : Anti-SLC12A6/KCC3 antibody (ab241348) at 0.1 µg/ml

    Lane 1 : HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 2 : HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
    Lane 3 : Jurkat (Human T cell leukemia cell line from peripheral blood) whole cell lysate

    Lysates/proteins at 50 µg per lane.

    Exposure time: 3 minutes


    Prepared using RIPA buffer.

References

ab241348 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab241348.
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