Key features and details
- Rabbit polyclonal to SLC16A3/MCT 4
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SLC16A3/MCT 4 antibody
See all SLC16A3/MCT 4 primary antibodies
DescriptionRabbit polyclonal to SLC16A3/MCT 4
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human SLC16A3/MCT 4 (internal sequence).
- Extracts from LOVO cells
Protein previously labeled as SLC16A3.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesThe antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Our Abpromise guarantee covers the use of ab74109 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 49 kDa.|
FunctionProton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Tissue specificityHighly expressed in skeletal muscle.
Sequence similaritiesBelongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Cellular localizationCell membrane.
- Information by UniProt
FormLactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 and MCT2, are characterized by 12 predicted transmembrane domains.
- MCT 4 antibody
- MCT3 antibody
- MCT4 antibody
ab74109 has been referenced in 5 publications.
- Sun K et al. Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling. EBioMedicine 41:370-383 (2019). PubMed: 30799198
- Chatel B et al. Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice. J Appl Physiol (1985) 122:1362-1369 (2017). PubMed: 28280108
- England EM et al. Chronic activation of AMP-activated protein kinase increases monocarboxylate transporter 2 and 4 expression in skeletal muscle. J Anim Sci 95:3552-3562 (2017). PubMed: 28805903
- Zawislak A et al. Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner. Oncotarget 8:106625-106638 (2017). PubMed: 29290976
- Ghorbel MT et al. Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury. BMC Genomics 15:916 (2014). PubMed: 25331815