Overview

  • Product name

  • Description

    Goat polyclonal to SLC17A5
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human SLC17A5 aa 85-99 (internal sequence) (Cysteine residue).
    Sequence:

    C-EHSAPIKVHHNQTGK


    Database link: Q9NRA2

  • Positive control

    • Human Placenta lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab174759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 55-60 kDa (predicted molecular weight: 54 kDa).

Target

  • Function

    Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
  • Tissue specificity

    Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.
  • Involvement in disease

    Salla disease
    Infantile sialic acid storage disorder
  • Sequence similarities

    Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
  • Cellular localization

    Cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AST antibody
    • H(+)/nitrate cotransporter antibody
    • H(+)/sialic acid cotransporter antibody
    • ISSD antibody
    • Membrane glycoprotein HP59 antibody
    • NSD antibody
    • S17A5_HUMAN antibody
    • SD antibody
    • Sialic acid storage disease antibody
    • Sialin antibody
    • SIASD antibody
    • Slc17a5 antibody
    • SLD antibody
    • Solute carrier family 17 (anion/sugar transportermember 5 antibody
    • Solute carrier family 17 member 5 antibody
    • Vesicular H(+)/Aspartate-glutamate cotransporter antibody
    see all

Images

  • Anti-SLC17A5 antibody (ab174759) at 1 µg/ml + Human Placenta lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 54 kDa
    Additional bands at: 55-60 kDa. We are unsure as to the identity of these extra bands.

References

ab174759 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab174759.
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