Key features and details
- Rabbit polyclonal to SLC29A3/ENT3 - N-terminal
- Suitable for: IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
Product nameAnti-SLC29A3/ENT3 antibody - N-terminal
DescriptionRabbit polyclonal to SLC29A3/ENT3 - N-terminal
ab211421 detects both isoforms of SLC29A3/ENT3. ab211421 is predicted not to cross-react with other SLC29 proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Rat, Human
Predicted to work with: Mouse
Synthetic peptide corresponding to Human SLC29A3/ENT3. (19 amino acid peptide from near the amino terminus; NP_060814.4).
Database link: Q9BZD2
This product was previously labelled as SLC29A3
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab211421 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 10 µg/ml.|
FunctionMediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.
Tissue specificityWidely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart.
Involvement in diseaseDefects in SLC29A3 are the cause of histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782]. A syndrome characterized by the combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct: Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy (SHML), H syndrome, and pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome (PHID). FHC features include joint deformities, sensorineural hearing loss, and subsequent development of generalized lymphadenopathy and swellings in the eyelids that contain histiocytes. SHML causes lymph node enlargement in children frequently accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. H syndrome is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism; hearing loss is found in about half of patients. PHID is characterized by predominantly antibody-negative insulin-dependent diabetes mellitus associated with pigmented hypertrichosis and variable occurrence of other features of H syndrome.
Sequence similaritiesBelongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Cellular localizationMembrane. Late endosome membrane. Lysosome membrane. Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface.
- Information by UniProt
- ENT3 antibody
- Equilibrative nucleoside transporter 3 antibody
- HCLAP antibody
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labeling SLC29A3/ENT3 with ab211421 at 10 µg/ml.
Immunohistochemical analysis of rat colon tissue labeling SLC29A3/ENT3 with ab211421 at 5 µg/ml.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling SLC29A3/ENT3 with ab211421 at 10 µg/ml.
ab211421 has not yet been referenced specifically in any publications.