Anti-SLC29A3/ENT3 antibody - N-terminal (ab211421)
Key features and details
- Rabbit polyclonal to SLC29A3/ENT3 - N-terminal
- Suitable for: IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-SLC29A3/ENT3 antibody - N-terminal -
Description
Rabbit polyclonal to SLC29A3/ENT3 - N-terminal -
Host species
Rabbit -
Specificity
ab211421 detects both isoforms of SLC29A3/ENT3. ab211421 is predicted not to cross-react with other SLC29 proteins.
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Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Rat, Human
Predicted to work with: Mouse
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Immunogen
Synthetic peptide corresponding to Human SLC29A3/ENT3. (19 amino acid peptide from near the amino terminus; NP_060814.4).
Database link: Q9BZD2 -
General notes
This product was previously labelled as SLC29A3
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab211421 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 10 µg/ml. |
Target
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Function
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. -
Tissue specificity
Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart. -
Involvement in disease
Defects in SLC29A3 are the cause of histiocytosis-lymphadenopathy plus syndrome (HLAS) [MIM:602782]. A syndrome characterized by the combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct: Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy (SHML), H syndrome, and pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome (PHID). FHC features include joint deformities, sensorineural hearing loss, and subsequent development of generalized lymphadenopathy and swellings in the eyelids that contain histiocytes. SHML causes lymph node enlargement in children frequently accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate, and polyclonal hypergammaglobulinemia. H syndrome is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism; hearing loss is found in about half of patients. PHID is characterized by predominantly antibody-negative insulin-dependent diabetes mellitus associated with pigmented hypertrichosis and variable occurrence of other features of H syndrome. -
Sequence similarities
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. -
Cellular localization
Membrane. Late endosome membrane. Lysosome membrane. Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface. - Information by UniProt
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Database links
- Entrez Gene: 55315 Human
- Entrez Gene: 71279 Mouse
- Entrez Gene: 353307 Rat
- Omim: 612373 Human
- SwissProt: Q9BZD2 Human
- SwissProt: Q99P65 Mouse
- SwissProt: Q80WK7 Rat
- Unigene: 438419 Human
see all -
Alternative names
- ENT3 antibody
- Equilibrative nucleoside transporter 3 antibody
- HCLAP antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC29A3/ENT3 antibody - N-terminal (ab211421)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labeling SLC29A3/ENT3 with ab211421 at 10 µg/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC29A3/ENT3 antibody - N-terminal (ab211421)Immunohistochemical analysis of rat colon tissue labeling SLC29A3/ENT3 with ab211421 at 5 µg/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC29A3/ENT3 antibody - N-terminal (ab211421)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling SLC29A3/ENT3 with ab211421 at 10 µg/ml.
Datasheets and documents
References (0)
ab211421 has not yet been referenced specifically in any publications.
