Anti-SLC31A1 / CTR1 antibody (ab133385)
Key features and details
- Rabbit polyclonal to SLC31A1 / CTR1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-SLC31A1 / CTR1 antibody
See all SLC31A1 / CTR1 primary antibodies -
Description
Rabbit polyclonal to SLC31A1 / CTR1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Hamster, Cow, Dog, Turkey, Pig, Xenopus laevis, Monkey, Gorilla, Opossum, Common marmoset, Orangutan, Platypus, Elephant -
Immunogen
Synthetic 16 amino acid peptide from internal region of Human SLC31A1/ CTR1
-
Positive control
- Human placenta tissue and Human lung (respiratory epithelium) tissue
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab133385 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 15 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
Notes |
---|
IHC-P
Use a concentration of 15 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
-
Function
High-affinity, saturable copper transporter involved in dietary copper uptake. -
Sequence similarities
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. -
Post-translational
modificationsO-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain. -
Cellular localization
Cell membrane. Localizes to the apical membrane in intestinal epithelial cells. - Information by UniProt
-
Database links
- Entrez Gene: 100689094 Hamster
- Entrez Gene: 1317 Human
- Entrez Gene: 20529 Mouse
- Entrez Gene: 397186 Pig
- Entrez Gene: 171135 Rat
- Omim: 603085 Human
- SwissProt: O15431 Human
- SwissProt: Q8K211 Mouse
see all -
Alternative names
- Copper transport 1 homolog antibody
- Copper transporter 1 antibody
- COPT1 antibody
see all
Images
-
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human placenta tissue labelling SLC31A1 / CTR1 with ab133385 at 15 µg/ml. Followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
-
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human lung, respiratory epithelium, tissue labelling SLC31A1 / CTR1 with ab133385 at 15 µg/ml. Followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Datasheets and documents
-
SDS download
-
Datasheet download
References (4)
ab133385 has been referenced in 4 publications.
- Zhang J et al. Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characterization in ovarian cancer. Cancer Cell Int 22:328 (2022). PubMed: 36307842
- Wu G et al. ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression. EBioMedicine 71:103558 (2021). PubMed: 34521054
- Parmar A et al. In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis. Theranostics 8:5645-5659 (2018). PubMed: 30555570
- Xia Y et al. Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma. Oncol Lett 14:5791-5800 (2017). PubMed: 29113209